The global burden of non-communicable diseases (NCDs) is rising, placing a significant burden on our societies, straining health systems and reducing workforce productivity. Today, NCDs are responsible for nearly 75% of all deaths globally, and cost over USD 2 trillion annually.1 Older people and people living with NCDs face higher risks of severe illness, complications, and death from vaccine-preventable diseases (VPDs), yet remain insufficiently prioritized in immunization strategies. While prevention is essential in reducing the impact of NCDs, immunization is often overlooked as a critical lever in both prevention and management.

Vaccines not only help prevent NCDs linked to infection, such as cancers caused by HPV and hepatitis B, but also protect older adults living with NCDs from infectious diseases like COVID-19, influenza, pneumococcal disease, and RSV.1 These infections can exacerbate chronic conditions, interrupt ongoing treatment, and lead to serious complications and long-term illness. Furthermore, growing evidence suggests that vaccines, by helping to prevent infections and reducing inflammation, can help protect the brain from long-term damage, potentially lowering the risk of dementia.2 Research has also shown that investing in adult immunization programs pays off. A study recently published by the Office of Health Economics has demonstrated that adult immunization programs that include people living with NCDs can offset their costs multiple times, yielding a return of up to 19 times their initial investment

This presentation will examine the power of adult immunization for older adults and people living with NCDs. It will highlight the urgent need to shift the mindset from treatment to prevention and to position immunization as a core component of integrated, life-course public health strategies. Drawing on real-world examples, including the integration of immunization into primary healthcare, chronic disease management pathways, and innovative delivery models such as community outreach and digital tools, it will illustrate practical, scalable solutions. We will explore four policy priorities essential for impact: enabling innovation, mobilizing investment, driving implementation through trusted healthcare providers, and ensuring accountability through integrated data systems and national NCD frameworks.1

The 2025 “Political Declaration on NCDs and Mental Health” and the midpoint of the “Immunization Agenda 2030” offer critical opportunities to place adult immunization at the heart of NCD prevention and control strategies. The presentation will also address equity challenges, including low awareness, geographic barriers, and under- prioritization in underserved populations, and propose people-centered approaches to improve access. Ultimately, immunization must be embedded, alongside other essential interventions, in a comprehensive approach to protect older people and high- risk groups – helping save lives, promote healthy ageing, and reinforce both health
system sustainability and economic resilience.