Multi-Domain Interventions to Effectively Reduce Cognitive Decline Globally in Populations 60 Years and Older
Presenter(s):
Ralph Martins, Alzheimer’s Research Australia, Australia
Abstract
The greatest risk factor for Dementia is ageing with 50% of people over the age of 85 succumbing to neurodegenerative disease. There is increasing evidence to show that lifestyle factors account for half the people who develop dementia. Thereby understanding modifiable dementia risk factors is crucial to reducing disease incidence. We and others globally have demonstrated that diet, exercise and brain training all contribute to the reduction in dementia risk. However the pioneering work of Professor Miia Kivipelto from Finland has provided striking evidence for the first time that a multidomain approach which includes diet, exercise, brain training and attention to vascular risk factors have the greatest impact on reducing cognitive decline. This latter study known as the FINGERS study has resulted in a global approach known as world wide FINGERS which are being investigated by several countries including Australia. The prevention clinical trial approach in Australia is known as the “AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention” (AU-ARROW). My presentation will discuss the AU-ARROW clinical trial and share the insights it has provided to date as well as the multidomain clinical trials globally that have already been completed.
The Australian findings highlight the necessity for dietary enhancements among AU-ARROW participants, which may vary by sex. A focus on improving adherence to MIND diet recommendations as well as other domains is required, not only for cognitive health, but also for general health and the prevention of other chronic diseases.
Bio(s):
Professor Ralph Martins, AO has dedicated over 40 years to Alzheimer’s Disease research.
He is well-known and highly respected internationally as a prominent researcher in the field.
His insight into this devastating disease has led to a number of ground-breaking discoveries. Professor Martins and his team have been at the forefront globally in developing non-invasive and cost-effective early diagnostics for pre-clinical Alzheimer’s disease.